Do not capitalize the words from which an acronym is derived (see 13.0, Abbreviations).
chronic obstructive pulmonary disease (COPD)
fluorescence in situ hybridization (FISH)
Exception: When the words that form the acronym are proper names, use capitals as described in 10.3.9, Proper Nouns, Official Names:
National Institute of Mental Health (NIMH)
When there has been a “stretch” to create a study name or a writing group name that is easy to say and somehow relates to the aim of the study but where the first letters of the major words do not match the acronym, do not use unusual capitalization to indicate how the study name was derived. Expanded study or group names use normal JAMA Network capitalization style.
Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE)
the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial